An Alternative Approach to Synthesize Sildenafil via Improved Copper-Catalyzed Cyclization

Author:

Odilov Abdullajon12ORCID,Gong Xudong3,Qin Hongjian24,Bonku Emmanuel Mintah12ORCID,Zhu Fuqiang3,Yang Feipu1ORCID,Shen Jingshan12ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

3. Topharman Shanghai Company, Ltd., Shanghai 201203, P. R. China

4. Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, P. R. China

Funder

Science and Technology Commission of Shanghai Municipality

Alliance of International Science Organizations

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Reference32 articles.

1. The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction

2. Sildenafil for Pulmonary Arterial Hypertension

3. Babos, B. P. S. M. Sildenafil. StatPearls (updated February 14, 2023).

4. Global Erectile Dysfunction Drugs Market By Drug Type (Viagra, Cialis, Stendra/Spedra, Zydena, Levitra/Staxyn, Vitaros, and, Other Drugs), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), By Region and Companies - Industry Segment Outlook, Market Assessment. Competition Scenario, Trends, and Forecast 2023–2032. https://market.us/report/erectile-dysfunction-drugs-market/#:~:text=Viagra%20(Sildenafil%20Citrate)%20holds%20a,market%20in%202022%20at%2051.7%25.

5. Bell, A. S.; Brown, D.; Terrett, N. K. Pyrazolopyrimidinone antianginal agents. BR9102560A, 1992.

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