Unexpected Cascade Sequence Forming the C(sp3)–N/C(sp2)–C(sp2) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity-Reference-Cited by-同舟云学术

Unexpected Cascade Sequence Forming the C(sp³)–N/C(sp²)–C(sp²) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity

Published:2023-06-06 Issue:13 Volume:88 Page:7998-8009
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

An Ya-Nan¹²,Huang Jiu-Hong¹,Xu Shi-Fang¹,Wang Xiao-Lin¹,Zhou Cheng-He²^ORCID,Xu Zhi-Gang¹^ORCID,Lei Jie¹,Chen Zhong-Zhu¹^ORCID

Affiliation:

1. College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing 402160, China

2. Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Funder

Chongqing Municipal Education Commission

Chongqing University of Arts and Sciences

Natural Science Foundation of Chongqing

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00031

Reference27 articles.

1. Total Synthesis of the Amaryllidaceae Alkaloid (+)-Plicamine and Its Unnatural Enantiomer by Using Solid-Supported Reagents and Scavengers in a Multistep Sequence of Reactions We gratefully acknowledge financial support from Pfizer Central Research for a Postdoctoral Fellowship (to I.R.B.), the BP endowment and the Novartis Research Fellowship (to S.V.L.), and Pharmacia & Upjohn (to C.P.).