A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist-Reference-Cited by-同舟云学术

A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist

Published:2021-06-14 Issue:13 Volume:86 Page:8851-8861
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kempson James¹^ORCID,Zhang Huiping¹,Hou Xiaoping¹^ORCID,Cornelius Lyndon¹^ORCID,Zhao Rulin¹,Wang Bei¹,Hong Zhenqiu¹,Oderinde Martins S.¹^ORCID,Pawluczyk Joseph¹,Wu Dauh-Rurng¹,Sun Dawn¹,Li Peng¹,Yip Shiuhang¹,Smith Aaron¹,Caceres-Cortes Janet¹,Aulakh Darpandeep²,Sarjeant Amy A.²,Park Peter K.¹,Harikrishnan Lalgudi S.¹,Qin Lan-ying¹,Dodd Dharmpal S.¹,Fink Brian¹,Vite Gregory¹,Mathur Arvind¹

Affiliation:

1. Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

2. Materials Science & Engineering, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c00784

Reference32 articles.

1. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2. cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!

3. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

4. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

5. Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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