Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents
Author:
Affiliation:
1. Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Wien, Austria
Funder
Austrian Science Fund
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c03158
Reference60 articles.
1. The Methylation Effect in Medicinal Chemistry
2. α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model
3. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions
4. Methyl-containing pharmaceuticals: Methylation in drug design
5. Smith, D.; Delost, M.; Qureshi, H.; Njarđarson, J. Top 200 pharmaceutical products by retail sales in 2016, 2017. http://njardarson.lab.arizona.edu/sites.
Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Nickel‐Catalyzed Chemodivergent Coupling of Alcohols: Efficient Routes to Access α,α‐Disubstituted Ketones and α‐Substituted Chalcones;Chemistry – A European Journal;2024-01-30
2. Allylation of C‐, N‐, and O‐Nucleophiles via a Mechanochemically‐Driven Tsuji–Trost Reaction Suitable for Late‐Stage Modification of Bioactive Molecules;Angewandte Chemie International Edition;2023-11-29
3. Allylation of C‐, N‐, and O‐Nucleophiles via a Mechanochemically‐Driven Tsuji–Trost Reaction Suitable for Late‐Stage Modification of Bioactive Molecules;Angewandte Chemie;2023-11-29
4. Ruthenium(II)-Catalyzed Hydrogenation and Tandem (De)Hydrogenation via Metal–Ligand Cooperation: Base- and Solvent-Assisted Switchable Selectivity;The Journal of Organic Chemistry;2022-10-25
5. Ruthenium-Catalyzed Monoselective C–H Methylation and d3-Methylation of Arenes;JACS Au;2022-10-21
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3