P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist-Reference-Cited by-同舟云学术

P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist

Published:2021-07-07 Issue: Volume: Page:
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zheng Bin¹^ORCID,Hang Chao¹,Zhu Jason¹,Purdum Geoffrey E.¹,Sezen-Edmonds Melda¹^ORCID,Treitler Daniel S.¹^ORCID,Yu Miao¹^ORCID,Yuan Changxia¹,Zhu Ye¹,Freitag Adam¹,Guo Siwei¹,Zhu Guanghui¹,Hritzko Ben¹,Paulson James¹,Shackman Jonathan G.¹,He Brian L.¹,Fu Weiqing¹,Tai Hua Chia¹,Ayers Sloan¹^ORCID,Park Hyunsoo¹,Eastgate Martin D.¹^ORCID,Cohen Ben¹^ORCID,Rogers Amanda¹,Wang Qinggang¹,Schmidt Michael A.¹^ORCID

Affiliation:

1. Bristol Myers Squibb, Chemical Process Development, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c01055

Reference12 articles.

1. An initial version of this work was deposited in ChemRxiv on Mar 12, 2021, reference P(III) vs. P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to An Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist (chemrxiv.org).

2. Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

3. Current patent and clinical status of stimulator of interferon genes (STING) agonists for cancer immunotherapy

4. Effect of deoxynucleoside phosphorothioates incorporated in DNA on cleavage by restriction enzymes.

5. The Thermodynamics of Phosphate versus Phosphorothioate Ester Hydrolysis

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