Can the −CF3 Group Act as a Tight, Well-Defined Hydrogen Bond Acceptor? A Clear Crystallographic CF2–F···H–N+ Interaction Says Yes-Reference-Cited by-同舟云学术

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Can the −CF₃ Group Act as a Tight, Well-Defined Hydrogen Bond Acceptor? A Clear Crystallographic CF₂–F···H–N⁺ Interaction Says Yes

Published:2024-06-19 Issue:13 Volume:89 Page:9681-9685
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Wang Muyuan¹,Garrison Nathaniel¹,Nguyen Phuong Minh¹,Prasad Aarush¹,Wang Yuang¹,Kwon Hyeok-Kyu¹,Kim Gina¹,Siegler Maxime A.¹^ORCID,Lectka Thomas¹^ORCID

Affiliation:

1. Department of Chemistry, Johns Hopkins University, 3400 North Charles St., Baltimore, Maryland 21218, United States

Funder

Division of Chemistry

NIH Office of the Director

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c00873

Reference25 articles.

1. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

2. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

3. FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years

4. Substitution Effect of the Trifluoromethyl Group on the Bioactivity in Medicinal Chemistry: Statistical Analysis and Energy Calculations

5. Introduction of Fluorine and Fluorine-Containing Functional Groups

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