Synthesis of (<i>Z</i>)-β-Chloro-enamides via a Base-Promoted <i>trans</i>-Hydroamidation of Alkynyl Chlorides Using 1,1-Dichloroalkenes as Precursor-Reference-Cited by-同舟云学术

Synthesis of (Z)-β-Chloro-enamides via a Base-Promoted trans-Hydroamidation of Alkynyl Chlorides Using 1,1-Dichloroalkenes as Precursor

Published:2022-06-10 Issue:13 Volume:87 Page:8764-8772
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zhang Zhenming¹^ORCID,Fu Bei¹,Wang Xiaoshuo¹,Hu Zhipeng¹,Liu Xuanling¹,Wang Tao¹,Zhao Junfeng¹²^ORCID

Affiliation:

1. National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China

2. Key Laboratory of Molecular Target & Clinical Pharmacology and the NMPA & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.2c00581

Reference55 articles.

1. Late Transition Metal-Catalyzed Hydroamination and Hydroamidation

2. The catalytic hydroamination of alkynes

3. Base-Mediated Hydroamination of Alkynes

4. Enamides: valuable organic substrates

5. Enamides and Enecarbamates as Nucleophiles in Stereoselective C–C and C–N Bond-Forming Reactions

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