An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3′-F2-BINOL
Author:
Affiliation:
1. Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.6b00189
Reference31 articles.
1. Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target
2. Functional Characterization of the Human 11β-Hydroxysteroid Dehydrogenase 1B (11β-HSD 1B) Variant
3. A Convergent Process for the Preparation of Adamantane 11-β-HSD-1 Inhibitors
4. Asymmetric Methallylation of Ketones Catalyzed by a Highly Active Organocatalyst 3,3′-F2-BINOL
5. Recent Progress in the Catalytic Synthesis of Tertiary Alcohols from Ketones with Organometallic Reagents
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