Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides-Reference-Cited by-同舟云学术

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides

Published:2016-03-04 Issue:6 Volume:81 Page:2261-2279
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kel′in Alexander V.¹,Zlatev Ivan¹,Harp Joel²,Jayaraman Muthusamy¹,Bisbe Anna¹,O′Shea Jonathan¹,Taneja Nate¹,Manoharan Rajar M.¹,Khan Saeed³,Charisse Klaus¹,Maier Martin A.¹,Egli Martin²,Rajeev Kallanthottathil G.¹,Manoharan Muthiah¹

Affiliation:

1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

2. Department of Biochemistry and Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

Funder

Basic Energy Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5b02375

Reference80 articles.

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4. http://www.alnylam.com/capella/presentations/12-month-clinical-data-from-patisiran-phase-2-open-label-extension-ole-study/.

5. http://www.alnylam.com/capella/presentations/aln-at3-isth-june2015/.

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