Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam-Reference-Cited by-同舟云学术

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

Published:2019-12-02 Issue:2 Volume:85 Page:464-481
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Khalifa Muhammad M.¹,Philkhana Satish Chandra¹,Golden Jennifer E.¹^ORCID

Affiliation:

1. Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin—Madison, 777 Highland Ave, Madison, Wisconsin 53703, United States

Funder

Wisconsin Alumni Research Foundation

American Foundation for Pharmaceutical Education

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b02541

Reference44 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Rings in Drugs

3. Quinoline, quinazoline and acridone alkaloids

4. Recent progress in the development of anti-malarial quinolones

5. Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1

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