Photo-Click-Facilitated Screening Platform for the Development of Hetero-Bivalent Agents with High Potency-Reference-Cited by-同舟云学术

Photo-Click-Facilitated Screening Platform for the Development of Hetero-Bivalent Agents with High Potency

Published:2020-03-30 Issue:9 Volume:85 Page:5771-5777
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Sun Lingyi¹²^ORCID,Gai Yongkang¹^ORCID,McNitt Christopher D.³,Sun Jun¹⁴,Zhang Xiaohui¹,Xing Wei⁴,Li Zhonghan²,Popik Vladimir V.³^ORCID,Zeng Dexing¹²^ORCID

Affiliation:

1. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States

2. Department of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon 97239, United States

3. Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States

4. Department of Radiology, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, China

Funder

Division of Chemistry

University of Pittsburgh Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

American Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b03122

Reference30 articles.

1. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

2. Multivalency in supramolecular chemistry and nanofabrication

3. Identification of Two Hydrophobic Patches in the Active-Site Cavity of Human Carbonic Anhydrase II by Solution-Phase and Solid-State Studies and Their Use in the Development of Tight-Binding Inhibitors

4. A heterodimeric [RGD-Glu-[64Cu-NO2A]-6-Ahx-RM2] αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors

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