3-Fluoroazetidinecarboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar

Author:

Liu Zilei1,Jenkinson Sarah F.1,Vermaas Tom1,Adachi Isao2,Wormald Mark R.3,Hata Yukako4,Kurashima Yukiko4,Kaji Akira4,Yu Chu-Yi56,Kato Atsushi2,Fleet George W. J.16

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.

2. Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan

3. Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K.

4. Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-1181, Japan

5. CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China

6. National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P.R. China

Funder

Leverhulme Trust

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

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