Stereochemical Analysis of Trifluoroacetamide Derivatives Based on Through-Space 1H–19F Spin

Stereochemical Analysis of Trifluoroacetamide Derivatives Based on Through-Space ¹H–¹⁹F Spin–Spin Couplings

Published:2023-05-18 Issue:11 Volume:88 Page:7026-7037
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Li Yan¹,Ohtake Chinatsu¹,Hotta Mayuno¹,Tabata Hidetsugu²^ORCID,Hirano Kiriko³,Iida Motoo¹,Nakamura Kayo¹,Makino Kosho⁴,Oshitari Tetsuta²^ORCID,Natsugari Hideaki⁵^ORCID,Kusumi Takenori⁶,Takahashi Hideyo¹^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan

2. Faculty of Pharma Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan

3. Bruker Japan K.K., 3-9 Moriya, Kanagawa-ku, Yokohama, Kanagawa 221-0022, Japan

4. Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi, Tokyo 202-8585, Japan

5. Graduate School of Pharmaceutical Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

6. Department of Chemistry, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00311

Reference25 articles.

1. Fluorine in Medicinal Chemistry

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3. Fluorine in medicinal chemistry

4. NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. LONG-RANGE SPIN-SPIN COUPLINGS IN SATURATED MOLECULES1

5. bDolbier, W. R. Guide to Fluorine NMR for Organic Chemists, 2nd ed. Wiley-VCH Press: NJ, 2016; pp 29–30.