Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency-Reference-Cited by-同舟云学术

Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency

Published:2016-12-12 Issue:1 Volume:82 Page:12-24
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Mitsuoka Yasunori¹²,Yamamoto Tsuyoshi¹,Kugimiya Akira²,Waki Reiko¹,Wada Fumito¹,Tahara Saori¹,Sawamura Motoki¹,Noda Mio¹,Fujimura Yuko²,Kato Yuki³,Hari Yoshiyuki¹⁴,Obika Satoshi¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita Osaka 565-0871, Japan

2. Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

3. Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan

4. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima 770-8514, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.6b02417

Reference46 articles.

1. Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

2. Antisense drug discovery and development

3. Antisense oligonucleotides: modifications and clinical trials

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