Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)-Reference-Cited by-同舟云学术

Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)

Published:2024-04-23 Issue:10 Volume:89 Page:6639-6650
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kempson James¹^ORCID,Zhao Rulin¹,Pawluczyk Joseph¹,Wang Bei¹,Zhang Huiping¹,Hou Xiaoping¹^ORCID,Allen Martin P.¹,Wu Dauh-Rurng¹,Li Peng¹,Yip Shiuhang¹,Smith Aaron¹,Traeger Sarah C.¹,Huang Stella¹,Cutrone Jingfang¹,Mukherjee Subha²^ORCID,Sfouggatakis Chris²,Poss Michael¹,Scola Paul M.¹,Meanwell Nicholas A.¹,Carter Percy H.¹^ORCID,Mathur Arvind¹

Affiliation:

1. Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

2. Chemical and Process Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c00429

Reference23 articles.

1. Cell-based peptide screening to access the undruggable target space

2. Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

3. New Modalities for Challenging Targets in Drug Discovery

4. mRNA display: from basic principles to macrocycle drug discovery

5. Ribosomal production and in vitro selection of natural product-like peptidomimetics: The FIT and RaPID systems

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