Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation-Reference-Cited by-同舟云学术

Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation

Published:2020-06-29 Issue:14 Volume:85 Page:9064-9070
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Tao Eriko¹,Inoue Masaki¹,Jeong Taejoo¹²,Kim In Su²^ORCID,Yoshimitsu Takehiko¹^ORCID

Affiliation:

1. Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

2. School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c00965

Reference35 articles.

1. Liphagal, a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge Aka coralliphaga: Structure Elucidation and Biomimetic Synthesis

2. The Phosphoinositide 3-Kinase Pathway

3. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

4. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents

5. Therapeutic Potential of Phosphoinositide 3-Kinase Inhibitors

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1. Organic redox cascade cyclization of 2-alkynylquinones by ascorbic acid in combination with a copper catalyst and its application to formal synthesis of liphagal;New Journal of Chemistry;2023

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