Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates-Reference-Cited by-同舟云学术

Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates

Published:2023-07-18 Issue:15 Volume:88 Page:10617-10631
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Takahashi Yuhei¹,Kakuta Kiyoshi¹,Namioka Yukichi¹,Igarashi Ayumi²,Sakamoto Taiichi³,Iwata Hara Rintaro¹⁴^ORCID,Sato Kazuki¹^ORCID,Wada Takeshi¹^ORCID

Affiliation:

1. Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

2. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8562, Japan

3. Department of Life Science, Chiba Institute of Technology, Graduate School of Advanced Engineering, Chiba 275-0016, Japan

4. Department of Neurology and Neurological Science, Graduate School of Medicinal and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan

Funder

Japan Agency for Medical Research and Development

Japan Science and Technology Agency

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00659

Reference31 articles.

1. Antisense technology: A review

2. Antisense technology: an overview and prospectus

3. Off-Target Effects Related to the Phosphorothioate Modification of Nucleic Acids

4. A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

5. Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

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