1. Graduate
School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
2. Pharmaceutical Research Center, Shionogi & Co. Ltd., Futaba-cho, Toyonaka, Osaka 561-0825, Japan
3. Laboratory
for Metabolomics, RIKEN Center for Integrative Medical Sciences, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan