Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach-Reference-Cited by-同舟云学术

Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach

Published:2016-10-18 Issue:22 Volume:81 Page:10930-10941
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Rycek Lukas¹,Hayward John J.¹,Latif Marwa Abdel²,Tanko James²,Simionescu Razvan¹,Hudlicky Tomas¹

Affiliation:

1. Department of Chemistry and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario L2S 3A1, Canada

2. Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States

Funder

Canada Foundation for Innovation

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

TDC Research Foundation

Advanced Biomanufacturing Centre, Brock University

Ontario Partnership for Innovation and Commercialization

College of Science, Virginia Polytechnic Institute and State University

TDC Research, Inc.

Noramco

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.6b01990

Reference23 articles.

1. Recent Progress in the Synthesis of Morphine Alkaloids

2. The Quest for a Practical Synthesis of Morphine Alkaloids and Their Derivatives by Chemoenzymatic Methods

3. Recent advances in process development for opiate-derived pharmaceutical agents

4. Synthetic opium alkaloids and derivatives. A short total synthesis of (.+-.)-dihydrothebainone, (.+-.)-dihydrocodeinone, and (.+-.)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners

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