Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations-Reference-Cited by-同舟云学术

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Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations

Published:2021-01-22 Issue:3 Volume:86 Page:2458-2473
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kwan Maria H. T.¹,Breen Jessica¹,Bowden Martin²,Conway Louis²,Crossley Ben³,Jones Martin F.⁴,Munday Rachel⁴,Pokar Nisha P. B.¹,Screen Thomas³,Blacker A. John¹^ORCID

Affiliation:

1. School of Chemistry and School of Chemical and Process Engineering. Institute of Process Research and Development. University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, U.K.

2. Syngenta, Jealott’s Hill, Bracknell, RG42 6EY, U.K.

3. ApexMolecular, Alderley Park, SK10 4TG, U.K.

4. Pharmaceutical Technology and Development, AstraZeneca, Macclesfield, SK10 2NA, U.K.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Pfizer UK

Innovate UK

Syngenta International

Dr Reddys

ApexMolecular

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c02617

Reference53 articles.

1. Controlled racemization of optically active organic compounds: Prospects for asymmetric transformation

2. Chiral Amine Synthesis

3. Li, W.; Zhang, X. Stereoselective formation of amines. Springer-Verlag: Berlin, Heidelberg, 2014.

4. Transaminase biocatalysis: optimization and application

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