Regioselective C3-Fluoroalcoholation of Indoles with Heptafluoroisopropyl Iodide via Palladium-Catalyzed C(sp2)–C(sp3) Cross-Coupling in the Presence of O2-Reference-Cited by-同舟云学术

Regioselective C3-Fluoroalcoholation of Indoles with Heptafluoroisopropyl Iodide via Palladium-Catalyzed C(sp²)–C(sp³) Cross-Coupling in the Presence of O₂

Published:2022-07-06 Issue:14 Volume:87 Page:9128-9138
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Qin Hong¹,Zhang Zhen¹,Qiao Kai¹,Chen Xinran¹,He Wei¹,Liu Chengkou¹,Yang Xiaobing²,Yang Zhao³,Fang Zheng¹⁴^ORCID,Guo Kai¹⁴^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, China

2. China Biology and Medicine Department, Jiangsu Industrial Technology Research Institute, Nanjing 210031, P. R. China

3. School of Engineering Institution, China Pharmaceutical University, No. 639 Longmian Avenue, Nanjing 211198, China

4. State Key Laboratory of Materials Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China

Funder

Natural Science Foundation of Jiangsu Province

Nanjing Tech University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.2c00802

Reference48 articles.

1. Fluorine in Pharmaceuticals: Looking Beyond Intuition

2. Applications of Fluorine in Medicinal Chemistry

3. Special applications of fluorinated organic compounds

4. Controlled Fluoroalkylation Reactions by Visible-Light Photoredox Catalysis

5. Recent advances in the synthesis of fluorinated hydrazones

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