Sequential Azidation/Azolation of Prenylated Derivatives and a Click Reaction Enable Selective Labeling and Degradation of RAS Protein-Reference-Cited by-同舟云学术

Sequential Azidation/Azolation of Prenylated Derivatives and a Click Reaction Enable Selective Labeling and Degradation of RAS Protein

Published:2023-07-18 Issue:15 Volume:88 Page:10836-10843
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Gan Youfang¹,Chen Xiaoqian¹,Li Yuanyuan¹,Guo Yuyang¹,Wang Rui¹²^ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

2. Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, Guangdong 518063, China

Funder

Huazhong University of Science and Technology

State Key Laboratory of Natural and Biomimetic Drugs

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00904

Reference40 articles.

1. Targeted protein posttranslational modifications by chemically induced proximity for cancer therapy

2. Systematic Functional Prioritization of Protein Posttranslational Modifications

3. Post-translational modifications in the context of therapeutic proteins

4. Deciphering Regulatory Proteins of Prenylated Protein via the FRET Technique Using Nitroso-Based Ene-Ligation and Sequential Azidation and Click Reaction

5. Development of Biocompatible Ene-Ligation Enabled by Prenyl-Based β-Caryophyllene with Triazoline/Selectfluor under Physiological Conditions

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