Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule Inhibitor of Protein Kinase C Epsilon-Reference-Cited by-同舟云学术

Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule Inhibitor of Protein Kinase C Epsilon

Published:2024-03-15 Issue:7 Volume:89 Page:5134-5141
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

De Kraker Harmannus¹,Wang Hua-Yu Leo¹,Arman Hadi D.¹,Renteria Rachel N.¹,Fleischer Caleb N.²,Messing Robert O.²,McHardy Stanton F.¹^ORCID

Affiliation:

1. Center for Innovative Drug Discovery, Department of Chemistry, University of Texas San Antonio, San Antonio, Texas 78254, United States

2. College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States

Funder

Congressionally Directed Medical Research Programs

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c02917

Reference22 articles.

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2. Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε

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4. Increased sensitivity to the aversive effects of ethanol in PKCε null mice revealed by place conditioning.

5. Critical role of nociceptor plasticity in chronic pain

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