Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry

Author:

Gondi Sudershan R.1ORCID,Shaik Althaf2,Westover Kenneth D.1ORCID

Affiliation:

1. Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States

2. Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Simkheda, Gandhinagar, Gujarat 382355, India

Funder

Office of Extramural Research, National Institutes of Health

Welch Foundation

Cancer Prevention and Research Institute of Texas

American Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference54 articles.

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2. Evers, M.; Genevois-Borella, A.; Karlsson, A.; Malleron, J.L. Preparation of 1-oxo-1,2-dihydroisoquinoline-5-carboxamide and 4-oxo-3,4-dihydroquinazoline-8-carboxamide derivatives as β-secretase inhibitors. WO Patent WO2009044018A2, 2009.

3. Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

4. Aquila, B.; Dakin, L.; Ezhuthachan, J.; Lee, J.; Lyne, P.; Pontz, T. Preparation of substituted quinazolones as B-Raf kinase inhibitors for the treatment of cancer. WO Patent WO2005123696A1, 2005.

5. Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

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