1. Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China, Instituto de Investigaciones Bioquímicas de Bahía Blanca and UNESCO Chair of Biophysics & Molecular Neurobiology, CC 857, B8000FWB, Bahía Blanca, Argentina, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China