1. Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, Division of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, Division of Kinetics and Metabolism, The Netherlands Organization for Applied Scientific Research (TNO) Quality of Life, Utrechtseweg 48, P.O. Box 360, 3700 AJ Zeist, and Wageningen University/TNO Centre for Food Toxicology, P.O. Box 8000, 6700 EA, Wageningen, The Netherlands