The Anti-Amyloidogenic Effect Is Exerted against Alzheimer's β-Amyloid Fibrils in Vitro by Preferential and Reversible Binding of Flavonoids to the Amyloid Fibril Structure

Author:

Hirohata Mie1,Hasegawa Kazuhiro1,Tsutsumi-Yasuhara Shinobu1,Ohhashi Yumiko1,Ookoshi Tadakazu1,Ono Kenjiro1,Yamada Masahito1,Naiki Hironobu1

Affiliation:

1. Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan, and CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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