3‘-Azido-3‘-deoxythymidine-(5‘)-tetraphospho-(5‘)-adenosine, the Product of ATP-Mediated Excision of Chain-Terminating AZTMP, Is a Potent Chain-Terminating Substrate for HIV-1 Reverse Transcriptase-Reference-Cited by-同舟云学术

3‘-Azido-3‘-deoxythymidine-(5‘)-tetraphospho-(5‘)-adenosine, the Product of ATP-Mediated Excision of Chain-Terminating AZTMP, Is a Potent Chain-Terminating Substrate for HIV-1 Reverse Transcriptase

Published:2006-12-21 Issue:3 Volume:46 Page:828-836
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Dharmasena Sanjeewa¹,Pongracz Zita¹,Arnold Eddy¹,Sarafianos Stefan G.¹,Parniak Michael A.¹

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi061364s

Reference33 articles.

1. Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus

2. Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo

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