Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2H-Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester-Reference-Cited by-同舟云学术

Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2H-Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester

Published:2013-12-09 Issue:1 Volume:18 Page:36-44
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Peng Zhihui¹,Ragan John A.¹,Colon-Cruz Roberto¹,Conway Brian G.¹,Cordi Eric M.¹,Leeman Kyle¹,Letendre Leo J.¹,Ping Li-Jen¹,Sieser Janice E.¹,Singer Robert A.¹,Sluggett Gregory W.¹,Strohmeyer Holly¹,Vanderplas Brian C.¹,Blunt Jon²,Mawby Nicola²,Meldrum Kevin²,Taylor Stuart²

Affiliation:

1. Chemical Research & Development and ‡Analytical Research & Development, Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut

2. Chemical Research & Development, Process Development Facility Ramsgate Road, Sandwich, Kent, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400236r

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3. Lewis Acid-Promoted Transesterification of N-Acyl Oxazolidinones under Mild Conditions

4. Total synthesis of taxane terpenes: cyclase phase

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