1. Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4965, Department of Ophthalmology, University of Washington, Seattle, Washington 98195, Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, and Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8