A QM/MM Free Energy Study of the Oxidation Mechanism of Dihydroorotate Dehydrogenase (Class 1A) from Lactococcus lactis-Reference-Cited by-同舟云学术

A QM/MM Free Energy Study of the Oxidation Mechanism of Dihydroorotate Dehydrogenase (Class 1A) from Lactococcus lactis

Published:2015-01-20 Issue:4 Volume:119 Page:1468-1473
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Silva José Rogério A.¹²,Roitberg Adrian E.²³,Alves Cláudio Nahum¹²

Affiliation:

1. Laboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA 66075-110, Brazil

2. Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States

3. Quantum Theory Project, University of Florida, Gainesville, Florida 32611-8435, United States

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp512860r

Reference69 articles.

1. Active Site of Dihydroorotate Dehydrogenase A from Lactococcus lactis Investigated by Chemical Modification and Mutagenesis

2. The crystal structure oflactococcus lactisdihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

3. Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat

4. Leflunomide: mode of action in the treatment of rheumatoid arthritis

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