Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin-Reference-Cited by-同舟云学术

Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

Published:2007-04-19 Issue:10 Volume:50 Page:2424-2431
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hulsman Niels¹,Medema Jan Paul¹,Bos Carina¹,Jongejan Aldo¹,Leurs Rob¹,Smit Martine J.¹,de Esch Iwan J. P.¹,Richel Dick¹,Wijtmans Maikel¹

Affiliation:

1. Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands, and Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061371e

Reference42 articles.

1. From magic bullets to designed multiple ligands

2. A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

3. NO-donating aspirin inhibits intestinal carcinogenesis in Min (APCMin/+) mice

4. Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

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