Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N-Myristoyltransferase and Identification of Related Tripeptide Inhibitors with Mechanism-Based Antifungal Activity-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N-Myristoyltransferase and Identification of Related Tripeptide Inhibitors with Mechanism-Based Antifungal Activity

Published:1997-08-01 Issue:16 Volume:40 Page:2609-2625
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Devadas Balekudru¹,Freeman Sandra K.¹,Zupec Mark E.¹,Lu Hwang-Fun¹,Nagarajan Srinivasan R.¹,Kishore Nandini S.¹,Lodge Jennifer K.¹,Kuneman David W.¹,McWherter Charles A.¹,Vinjamoori Dutt V.¹,Getman Daniel P.¹,Gordon Jeffrey I.¹,Sikorski James A.¹

Affiliation:

1. Department of Medicinal and Structural Chemistry, G. D. Searle and Company, 700 Chesterfield Parkway North, St. Louis, Missouri 63198, Department of Analytical Chemistry, Monsanto Corporate Research, Monsanto Company, 800 North Lindbergh Boulevard, St. Louis, Missouri 63167, and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970094w

Reference29 articles.

1. GENETIC AND BIOCHEMICAL STUDIES OF PROTEIN N-MYRISTOYLATION

2. Understanding covalent modifications of proteins by lipids: where cell biology and biophysics mingle

3. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

4. Disruption of the Yeast N -Myristoyl Transferase Gene Causes Recessive Lethality

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