Computational Evidence for α-Nitrosamino Radical as Initial Metabolite for Both the P450 Dealkylation and Denitrosation of Carcinogenic Nitrosamines-Reference-Cited by-同舟云学术

Computational Evidence for α-Nitrosamino Radical as Initial Metabolite for Both the P450 Dealkylation and Denitrosation of Carcinogenic Nitrosamines

Published:2012-01-09 Issue:2 Volume:116 Page:903-912
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Ji Li¹,Schüürmann Gerrit¹

Affiliation:

1. UFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318 Leipzig, Germany, and Institute for Organic Chemistry, Technical University Bergakademie Freiberg, Leipziger Strasse 29, 09596 Freiberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp206570n

Reference56 articles.

1. Metabolic activation of carcinogens

2. Structure-activity relations in carcinogenesis by N-nitroso compounds

3. The Structure of DNA Dictates Purine Atom Site Selectivity in Alkylation by Primary Diazonium Ions

4. Oxidation of N-Nitrosoalkylamines by Human Cytochrome P450 2A6

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