PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity-Reference-Cited by-同舟云学术

PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity

Published:2006-01-10 Issue:3 Volume:49 Page:1157-1164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saavedra Joseph E.¹,Srinivasan Aloka¹,Buzard Gregory S.¹,Davies Keith M.¹,Waterhouse David J.¹,Inami Keiko¹,Wilde Thomas C.¹,Citro Michael L.¹,Cuellar Matthew¹,Deschamps Jeffrey R.¹,Parrish Damon¹,Shami Paul J.¹,Findlay Victoria J.¹,Townsend Danyelle M.¹,Tew Kenneth D.¹,Singh Shivendra¹,Jia Lee¹,Ji Xinhua¹,Keefer Larry K.¹

Affiliation:

1. Basic Research Program, SAIC Frederick, Chemistry Section, Laboratory of Comparative Carcinogenesis, and Biomolecular Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702; Department of Chemistry, George Mason University, Fairfax, Virginia 22030; Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, District of Columbia 20375; Division of Medical Oncology, Department of Internal Medicine, University of...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050700k

Reference12 articles.

1. Tumor Cell Responses to a Novel GlutathioneS-Transferase–Activated Nitric Oxide-Releasing Prodrug

2. The Secondary Amine/Nitric Oxide Complex Ion R2N[N(O)NO]- as Nucleophile and Leaving Group in SNAr Reactions

3. S-Nitrosothiol detection

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