A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation-Reference-Cited by-同舟云学术

A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Published:1996-01-01 Issue:30 Volume:35 Page:9737-9745
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Fan Naisheng¹,Rank Kenneth B.¹,Slade David E.¹,Poppe Susan M.¹,Evans David B.¹,Kopta Laurice A.¹,Olmsted Robert A.¹,Thomas Richard C.¹,Tarpley W. Gary¹,Sharma Satish K.¹

Affiliation:

1. Biochemistry, Cancer and Infectious Diseases Research, and Medicinal Chemistry, Upjohn Laboratories, Kalamazoo, Michigan 49001

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi9600308

Reference45 articles.

1. Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem

2. Amino acid substitutions in HIV-1 reverse transcriptase with corresponding residues from HIV-2. Effect on kinetic constants and inhibition by non-nucleoside analogs

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