Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein: Evidence for Formation of the E·S Reaction Intermediate with ATP-γ-S, a Nonhydrolyzable Analogue of ATP-Reference-Cited by-同舟云学术

Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein: Evidence for Formation of the E·S Reaction Intermediate with ATP-γ-S, a Nonhydrolyzable Analogue of ATP

Published:2007-11-08 Issue:48 Volume:46 Page:13787-13799
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Sauna Zuben E.¹,Kim In-Wha¹,Nandigama Krishnamachary¹,Kopp Stephan¹,Chiba Peter¹,Ambudkar Suresh V.¹

Affiliation:

1. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4256, and Institute of Medicinal Chemistry, Medical University of Vienna, Waehringerstrasse 10, Vienna, A-1090 Austria

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi701385t

Reference55 articles.

1. EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES

2. Multidrug resistance in cancer: role of ATP–dependent transporters

3. The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

4. The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)

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