Total Syntheses of Thailanstatins A–C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents-Reference-Cited by-同舟云学术

Total Syntheses of Thailanstatins A–C, Spliceostatin D, and Analogues Thereof. Stereodivergent Synthesis of Tetrasubstituted Dihydro- and Tetrahydropyrans and Design, Synthesis, Biological Evaluation, and Discovery of Potent Antitumor Agents

Published:2018-06-26 Issue:26 Volume:140 Page:8303-8320
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nicolaou K. C.¹^ORCID,Rhoades Derek¹^ORCID,Kumar S. Mothish¹

Affiliation:

1. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Funder

Welch Foundation

Cancer Prevention and Research Institute of Texas

National Institutes of Health

AbbVie Stemcentrx, LLC.

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.8b04634

Reference125 articles.

1. Alternative splicing: the pledge, the turn, and the prestige

2. The Spliceosome: A Protein-Directed Metalloribozyme

3. The spliceosome as a target of novel antitumour drugs

4. Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms

5. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

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