Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma

Author:

Wu Hong12,Wang Wenchao1,Liu Feiyang12,Weisberg Ellen L.3,Tian Bei4,Chen Yongfei1,Li Binhua1,Wang Aoli1,Wang Beilei1,Zhao Zheng1,McMillin Douglas W.3,Hu Chen1,Li Hong1,Wang Jinhua5,Liang Yanke5,Buhrlage Sara J.5,Liang Junting6,Liu Jing1,Yang Guang37,Brown Jennifer R.3,Treon Steven P.37,Mitsiades Constantine S.3,Griffin James D.3,Liu Qingsong12,Gray Nathanael S.5

Affiliation:

1. High Magnetic Field laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China

2. University of Science and Technology of China, Hefei 230036, Anhui, P. R. China

3. Department of Medical Oncology, Dana−Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, Massachusetts 02115, United States

4. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Science Key Laboratory, Beijing 100730, P. R. China

5. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, SGM 628, Boston, Massachusetts 02115, United States

6. Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China

7. Bing Center for Waldenström’s Macroglobulinemia, Dana−Farber Cancer Institute, M547, 450 Brookline Avenue, Boston, Massachusetts 02115, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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