Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists
Author:
Affiliation:
1. Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm301276e
Reference33 articles.
1. Strategies to improve plasma half life time of peptide and protein drugs
2. Measuring net protease activities in biological samples using selective peptidic inhibitors
3. Strategies for extended serum half-life of protein therapeutics
4. Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats
5. Proteases Universally Recognize Beta Strands In Their Active Sites
Cited by 49 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Lipidation and PEGylation strategies to prolong the in vivo half-life of a nanomolar EphA4 receptor antagonist;European Journal of Medicinal Chemistry;2023-12
2. A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue;Bioorganic & Medicinal Chemistry;2023-11
3. Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo;Nature Communications;2023-09-13
4. Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2;Nature Communications;2023-06-16
5. Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate;BioFactors;2022-11-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3