Preparative Chromatography with Extreme Productivity: HPLC Preparation of an Isomerically Pure Drug Intermediate on Multikilogram Scale-Reference-Cited by-同舟云学术

Preparative Chromatography with Extreme Productivity: HPLC Preparation of an Isomerically Pure Drug Intermediate on Multikilogram Scale

Published:2009-03-25 Issue:3 Volume:13 Page:621-624
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Welch Christopher J.¹,Henderson Derek W.¹,Tschaen David M.¹,Miller Ross A.¹

Affiliation:

1. Separation and Purification Center of Excellence, Department of Process Research, Merck & Co., Inc., Rahway, New Jersey 07065, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op900035y

Reference7 articles.

1. Chromatography as an Enabling Technology in Pharmaceutical Process Development: Expedited Multikilogram Preparation of a Candidate HIV Protease Inhibitor

2. Welch, C. J.InPreparative Enantioselective Chromatography;Cox, G., Ed.Blackwell:London, 2005; pp1−18.

3. Strategic use of preparative chiral chromatography for the synthesis of a preclinical pharmaceutical candidate

4. Microscale HPLC Predicts Preparative Performance at Millionfold Scale

5. Rault, J.; Dupraz, C.; Montecot, F.Alternative routes to paraxylene production.Petrochemicals and Gas Processing,Petroleum Technology Quarterly, Spring, 2004; pp123−129.http://www.axens.net/upload/news/fichier/ptq_spring2004.pdf.

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