1. Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan
2. Department of Internal Medicine, China Medical University, Taichung 404, Taiwan
3. Department of Pharmacology
4. Graduate Institutes of Chinese Medical Science, China Medical University, Taichung 404, Taiwan
5. Department of Life Sciences
6. Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung 404, Taiwan
7. Division of Cardiology, China Medical University Hospital, Taichung 404, Taiwan
8. Department of Pharmacology, School of Medicine and Geriatric Research, Education and Clinical Center, VA Medical Center, University of Minnesota, Minneapolis, Minnesota 55417