Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors-Reference-Cited by-同舟云学术

Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

Published:2012-10-11 Issue:20 Volume:55 Page:8827-8837
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crawford James J.¹,Kenny Peter W.¹,Bowyer Jonathan¹,Cook Calum R.¹,Finlayson Jonathan E.¹,Heyes Christine¹,Highton Adrian J.¹,Hudson Julian A.¹,Jestel Anja²,Krapp Stephan²,Martin Scott¹,MacFaul Philip A.¹,McDermott Benjamin P.¹,McGuire Thomas M.¹,Morley Andrew D.¹,Morris Jeffrey J.¹,Page Ken M.¹,Ribeiro Lyn Rosenbrier¹,Sawney Helen¹,Steinbacher Stefan²,Smith Caroline¹,Dossetter Alexander G.¹

Affiliation:

1. AstraZeneca R&D, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

2. Proteros Biostructures, Am Klopferspitz 19, D-82152 Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301119s

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1. Bone Resorption by Osteoclasts

2. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II