Estimation of the Unbound Brain Concentration of P-Glycoprotein Substrates or Nonsubstrates by a Serial Cerebrospinal Fluid Sampling Technique in Rats-Reference-Cited by-同舟云学术

Estimation of the Unbound Brain Concentration of P-Glycoprotein Substrates or Nonsubstrates by a Serial Cerebrospinal Fluid Sampling Technique in Rats

Published:2014-01-09 Issue:2 Volume:11 Page:477-485
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Mariappan T. Thanga¹,Kurawattimath Vishwanath¹,Gautam Shashyendra Singh¹,Kulkarni Chetan P.¹,Kallem Rajareddy¹,Taskar Kunal S.¹,Marathe Punit H.²,Mandlekar Sandhya³

Affiliation:

1. Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Syngene International Ltd., Biocon Park, Plot 2 & 3, Bommasandra IV Phase, Bangalore 560 099, India

2. Pharmaceutical Candidate Optimization, Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Pennington, New Jersey 08534, United States

3. Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre (BBRC), Bristol-Myers Squibb India Ltd., Bangalore 560099, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp400436d

Reference32 articles.

1. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

2. Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

3. In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

4. The brain slice method for studying drug distribution in the CNS

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