Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase

Author:

Stephens Erin A.1,Ludwicki Morgan B.2,Meksiriporn Bunyarit3,Li Mingji2,Ye Tianzheng2,Monticello Connor3,Forsythe Katherine J.4,Kummer Lutz5,Zhou Pengbo6,Plückthun Andreas5ORCID,DeLisa Matthew P.123ORCID

Affiliation:

1. Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, United States

2. Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States

3. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, United States

4. College of Arts and Sciences, Cornell University, Ithaca, New York 14853, United States

5. Department of Biochemistry, University of Zürich, 8057 Zürich, Switzerland

6. Department of Pathology and Laboratory Medicine, The Joan and Stanford I. Weill Medical College of Cornell University, New York, New York 10065, United States

Funder

National Cancer Institute

New York State Foundation for Science, Technology and Innovation

Division of Graduate Education

Office of the Civil Service Commission

Cornell University

Defense Threat Reduction Agency

Division of Chemical, Bioengineering, Environmental, and Transport Systems

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

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