Integration of Yeast Episomal/Integrative Plasmid Causes Genotypic and Phenotypic Diversity and Improved Sesquiterpene Production in Metabolically Engineered Saccharomyces cerevisiae

Author:

Peng Bingyin123ORCID,Weintraub Sarah J.4,Lu Zeyu123,Evans Samuel12,Shen Qianyi1235,McDonnell Liam12,Plan Manuel36,Collier Thomas17ORCID,Cheah Li Chen13,Ji Lei8,Howard Christopher B.3ORCID,Anderson Will3,Trau Matt35ORCID,Dumsday Geoff9,Bredeweg Erin L.10,Young Eric M.11ORCID,Speight Robert1212ORCID,Vickers Claudia E.12

Affiliation:

1. ARC Centre of Excellence in Synthetic Biology, Sydney, NSW 2109, Australia

2. Centre of Agriculture and the Bioeconomy, School of Biology and Environmental Science, Faculty of Science, Queensland University of Technology, Brisbane, QLD 4000, Australia

3. Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia

4. Bioinformatics and Computational Biology, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States of America

5. School of Chemistry and Molecular Biosciences (SCMB), The University of Queensland, Brisbane, QLD4072, Australia

6. Metabolomics Australia (Queensland Node), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia

7. School of Natural Sciences, Macquarie University, Sydney, NSW 2109, Australia

8. Shandong Provincial Key Laboratory of Applied Microbiology, Ecology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China

9. CSIRO Manufacturing, Clayton, VIC 3169, Australia

10. Functional and Systems Biology Group, Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States

11. Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States

12. Advanced Engineering Biology Future Science Platform, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Black Mountain, ACT 2601, Australia

Funder

Australian Research Council

Commonwealth Scientific and Industrial Research Organisation

University of Queensland

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

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