Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity

Author:

Wang Yuyang12,He Jianqiao12,Alam Md Shah3456,Wang Fang7,Shang Zhuo8,Chen Yingying1,Sun Changli1,Lu Ziwen3456,Gao Yamin3456,Zhang Tianyu3456ORCID,Ju Jianhua12ORCID,Ma Junying12ORCID

Affiliation:

1. CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Haizhu District, Guangzhou 510301, Guangdong, China

2. College of Oceanology, University of Chinese Academy of Sciences, Qingdao 266400, China

3. Tuberculosis Research Laboratory, State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Huangpu District, Guangzhou 510530, China

4. Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou 510530, China

5. China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

6. University of Chinese Academy of Sciences, Beijing 100049, China

7. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, Yuexiu District, Guangzhou 510060, China

8. School of Pharmaceutical Sciences, Shandong University, Lixia District, Jinan 250012, Shandong, China

Funder

National Key Research and Development Program of China

Basic and Applied Basic Research Foundation of Guangdong Province

Guangdong Provincial Pearl River Talents Program

Major Science and Technology Project of Hainan Province

National Natural Science Foundation of China

South China Sea Institute of Oceanology, Chinese Academy of Sciences

Shenzhen Bay Laboratory

Publisher

American Chemical Society (ACS)

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