A Cascade Signal Amplification Based on Dynamic DNA Nanodevices and CRISPR/Cas12a Trans-cleavage for Highly Sensitive MicroRNA Sensing

Author:

Li Xingrong1,Zhang Decai23,Gan Xiufeng1,Liu Ping1,Zheng Qingyuan1,Yang Tiantian2,Tian Guozhen4,Ding Shijia1ORCID,Yan Yurong1ORCID

Affiliation:

1. Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China

2. The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

3. Department of Laboratory Diagnosis, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518000, China

4. Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, 571199, China

Funder

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Chongqing

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

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