Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells

Author:

Veling Mike T.12ORCID,Nguyen Dan T.12ORCID,Thadani Nicole N.1,Oster Michela E.12ORCID,Rollins Nathan J.12,Brock Kelly P.1,Bethel Neville P.34,Lim Samuel12,Baker David345,Way Jeffrey C.12,Marks Debora S.16,Chang Roger L.127,Silver Pamela A.12ORCID

Affiliation:

1. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States

2. Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, United States

3. Institute for Protein Design, University of Washington, Seattle, Washington 98195, United States

4. Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States

5. Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, United States

6. Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States

7. Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York 10461, United States

Funder

Howard Hughes Medical Institute

National Cancer Institute

Defense Advanced Research Projects Agency

Army Research Office

Harvard Medical School

Chan Zuckerberg Initiative

National Science Foundation

Wyss Institute for Biologically Inspired Engineering, Harvard University

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

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