Directed Evolution of (<i>R</i>)-2-Hydroxyglutarate Dehydrogenase Improves 2-Oxoadipate Reduction by 2 Orders of Magnitude-Reference-Cited by-同舟云学术

Directed Evolution of (R)-2-Hydroxyglutarate Dehydrogenase Improves 2-Oxoadipate Reduction by 2 Orders of Magnitude

Published:2022-08-08 Issue:8 Volume:11 Page:2779-2790
ISSN:2161-5063
Container-title:ACS Synthetic Biology
language:en
Short-container-title:ACS Synth. Biol.

Author:

Saez-Jimenez Veronica¹,Scrima Simone²³,Lambrughi Matteo²,Papaleo Elena²³^ORCID,Mapelli Valeria¹^ORCID,Engqvist Martin K. M.⁴^ORCID,Olsson Lisbeth¹

Affiliation:

1. Division of Industrial Biotechnology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden

2. Cancer Structural Biology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark

3. Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, 2800 Lyngby, Denmark

4. Division of Systems and Synthetic Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden

Funder

Danmarks Grundforskningsfond

Novo Nordisk Fonden

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Biomedical Engineering,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acssynbio.2c00162

Reference32 articles.

1. Toward biotechnological production of adipic acid and precursors from biorenewables

2. Biological production of adipic acid from renewable substrates: Current and future methods